Deoxynivalenol Exacerbates Viral Bronchopneumonia Induced by Respiratory Reovirus Infection
نویسندگان
چکیده
منابع مشابه
Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection.
The trichothecene mycotoxin deoxynivalenol (DON), a frequent contaminant of cereal grains, is known to dysregulate mucosal and systemic immunity. In this study, we tested the hypothesis that DON interferes with the murine immune response to viral respiratory infection. Female Balb/c mice (5 weeks old) were orally gavaged with DON (10 mg/kg body weight [bw]) or saline vehicle and then intranasal...
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Based on the known capacity of deoxynivalenol (DON) to target gut lymphoid tissue and IgA production, it was hypothesized that this mycotoxin interferes with the immune response to enteric reovirus infection. When mice were orally gavaged, first with 25 mg/kg bw DON, and then with reovirus serotype 1, strain Lang (T1/L) 2 or 12 h later, viral titers in the GI tract were 10-fold higher than cont...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2006
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfl153